RNA Therapeutics

The continuous discovery of RNA functions and their crucial roles in disease have led to tremendous growth in RNA-based therapeutic development, specifically messenger RNA (mRNA). Increasing numbers of RNA therapeutics have been approved for clinical use and many others are still under investigation or in preclinical trials, spanning vaccine development, immuno-oncology, and other gene therapies. However, as a new frontier in therapeutics and due to their differences from small molecules and other biologics, RNA-based therapies present new process development and analytical challenges from discovery through commercialization.

TARGET DISCOVERY

Identify and validate the most promising targets for therapeutic development

Find samples that match your specific requirements to ensure your R&D success with sample sourcing
Leverage high-throughput-gene expression screening for optimal drug discovery with complete cell-to-data analysis of the transcriptome
Identify the full catalog of transcripts, precisely define the structure of genes, and accurately measure gene expression levels with RNA sequencing (RNA-Seq)
Use Olink Target 48, Target 96, and Explore 3072/384 panels to support various stages and applications of protein biomarker discovery
Ensure reproducible results with high-quality sample tubes, low-binding microplates, and other consumables

RNA DESIGN & DEVELOPMENT

Design and produce your therapeutic product

Use mRNA synthesis for the fastest and most reliable product development with 100% Sanger-verified template gene synthesis and in vitro transcription (IVT) in as fast as 2 weeks
Interrogate gene function and control gene expression with custom DNA & RNA oligos
Generate lentiviral vectors starting with construct synthesis through viral production and storage of the transduction-ready virus; robust lentiviral integration site analysis* is available as a separate offering
Maintain the integrity of ITR regions for reliable downstream application of AAV vectors with proprietary AAV plasmid synthesis
Ensure reproducible results with high-quality sample tubes, low-binding microplates, and other consumables
Utilize sample storage, transport, and annotation services for better sample management

*Analytically validated or fit-for-purpose assays for viral integration site analysis (ISA) are performed in our CAP/CLIA-accredited laboratory

RNA PRODUCT VALIDATION

Perform in-depth sequencing and functional analysis of your RNA product

Rely on our team of assay experts to develop qPCR assays for RNA analysis
Fulfill your RNA sequencing (RNA-Seq) project needs with a variety of solutions, including small RNA-Seq and single-cell RNA-Seq
Simultaneously analyze proteins with high specificity and sensitivity using minimal sample amounts with Olink assays
Detect mutations with assays that cover full coding exons, coding exons of Interest, and introns
Ensure reproducible results with high-quality sample tubes, low-binding microplates, and other consumables
Utilize sample storage, transport, and annotation services for better sample management

PRECLINICAL & CLINICAL

Prepare for regulatory submissions

Validate protein response in clinical trials and other clinical applications with Olink assays performed in our CLIA/CAP laboratory
Probe coding regions of the genome at high depth and with uniform coverage with CLIA-compliant whole genome or exome sequencing
Support your analysis with ultra-deep amplicon sequencing options, including custom short- or long-read amplicon sequencing services
Verify the sequence of your product with GLP-compliant confirmatory sequencing solutions, from nucleic acid extraction to Sanger sequencing with thorough quality assurance program
Ensure reproducible results with high-quality sample tubes, low-binding microplates, and other consumables
Utilize sample storage, transport, and annotation services for better sample management